Factores epigenéticos y de estilo de vida en la salud nutricional e inmunológica
DOI:
https://doi.org/10.56048/MQR20225.9.3.2025.e841Palabras clave:
Epigenética; Enfermedades autoinmunes; Estilo de vida; Salud nutriciónResumen
Los factores epigenéticos y el estilo de vida influyen en la salud nutricional e inmunológica, modulando el metabolismo, la inflamación y la respuesta inmune. El objetivo de la investigación fue analizar los factores epigenéticos y de estilo de vida en la salud nutricional e inmunológica. La metodología aplicada en la investigación fue de diseño documental de tipo descriptivo. Se realizó la búsqueda de artículos publicados en bases de datos; PubMed, Dialnet, Elsevier, Google Académico, Scielo y Multidisciplinario de Publicaciones Digitales, se tomaron en consideración criterios de inclusión y exclusión estudios que correspondan al periodo de los últimos 10 años comprendidos 2015 – 2024 en español e inglés. Los resultados indicaron que los factores epigenéticos en la salud nutricional se asocian con el retraso fetal, defectos del tubo neural, obesidad infantil, hígado graso, aterosclerosis y dislipidemia. Al mismo tiempo, los factores epigenéticos y la salud inmunológica favorecen las enfermedades autoinmunes, inflamatorias y cáncer. Así la hipermetilación de BRCA1 y hipermetilación PD-L1 favorece tumores agresivos; la expresión alterada de HDAC1 bloquea apoptosis en linfocitos; contribuye a leucemia mieloide. Con esto se concluye que los factores epigenéticos regulan procesos metabólicos e inmunológicos esenciales, influyendo en la salud y en la susceptibilidad a diversas enfermedades.
Resumen del artículo, en idioma español.
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